INT327971

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BAX) small molecule metabolic process (PNLIP) endoplasmic reticulum (BAX)
cytoplasm (BAX) lipid metabolic process (PNLIP) cytosol (BAX)
Anatomy Link Frequency
BxPC-3 2
PNLIP (Homo sapiens)
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 102 98.76 Very High Very High Very High
Pancreatic Cancer 63 92.84 High High
Injury 30 72.24 Quite High
Metastasis 6 59.20 Quite High
Death 6 27.88 Quite Low
Aggression 6 24.40 Low Low
Cancer 42 19.84 Low Low
Parkinson's Disease 6 5.00 Very Low Very Low Very Low
Adenocarcinoma 3 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTL downregulated Bcl-2 and upregulated Bax expression.
PTL Positive_regulation (upregulated) of Gene_expression (expression) of Bax
1) Confidence 0.43 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.82 Pain Relevance 0
PTL obviously decreased the protein expression of antiapoptotic Bcl-2 and increased the protein expression of proapoptotic Bax in the BxPC-3 cells after being treated with indicated concentrations.
PTL Positive_regulation (increased) of Gene_expression (expression) of Bax in BxPC-3
2) Confidence 0.37 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.54 Pain Relevance 0
In Bcl-2 family members, the expression of Bcl-2, Bax and Bad after PTL treatment for 48 hours were detected by Western blotting (Fig. 5A).
PTL Positive_regulation (after) of Gene_expression (expression) of Bax
3) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.59 Pain Relevance 0

General Comments

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