INT328226

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.49
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
poly 2
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 45 99.84 Very High Very High Very High
Pyramidal cell 1 93.68 High High
Inflammation 44 90.72 High High
COX-2 inhibitor 4 86.40 High High
Paracetamol 1 68.96 Quite High
Hippocampus 1 68.64 Quite High
cerebral cortex 2 68.00 Quite High
agonist 2 37.32 Quite Low
cytokine 17 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 127 98.54 Very High Very High Very High
Stress 14 98.26 Very High Very High Very High
Neurodegenerative Disease 16 94.40 High High
INFLAMMATION 62 90.72 High High
Alzheimer's Dementia 7 72.32 Quite High
Amyloid Plaque 3 70.72 Quite High
Injury 5 62.12 Quite High
Infection 17 5.00 Very Low Very Low Very Low
Schizophrenia 9 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Referring to the oxidative stress underlying AD pathology, one further aspect of these reactive oxygen species includes activation of COX-1/2, which are blocked by NSAIDs.
Negative_regulation (blocked) of Positive_regulation (activation) of COX associated with stress, cinod and disease
1) Confidence 0.11 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2925207 Disease Relevance 1.02 Pain Relevance 0.44
Treatment with the nonselective cyclooxygenase (COX) inhibitor carprofen prevents poly(I ? 
Negative_regulation (inhibitor) of Positive_regulation (nonselective) of COX in poly
2) Confidence 0.10 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.46 Pain Relevance 0.23
M indomethacin (a non-specific COX and LOX inhibitor) with 100 ?
Negative_regulation (inhibitor) of Positive_regulation (specific) of COX
3) Confidence 0.03 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0.07

General Comments

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