INT32835

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Context Info
Confidence 0.10
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.65
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde3a) signal transduction (Pde3a)
Anatomy Link Frequency
brain stem 2
pulmonary artery 1
Pde3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 2 99.04 Very High Very High Very High
analgesia 6 97.12 Very High Very High Very High
depression 2 87.80 High High
Restless leg syndrome 2 82.52 Quite High
Pain 2 57.60 Quite High
aspirin 1 36.88 Quite Low
anesthesia 1 25.00 Low Low
antagonist 8 18.24 Low Low
imagery 14 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 68 99.56 Very High Very High Very High
Hiatal Hernia 222 96.08 Very High Very High Very High
Increased Venous Pressure Under Development 11 95.44 Very High Very High Very High
Hypothermia 2 95.36 Very High Very High Very High
Cv Unclassified Under Development 2 95.28 Very High Very High Very High
Peripheral Arterial Disease 6 93.40 High High
Disease 12 88.64 High High
Depression 2 87.80 High High
Death 7 86.84 High High
Stroke 1 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drugs used were pimobendan, a selective PDE III inhibitor, rolipram, a selective PDE IV inhibitor, and zaprinast, a selective PDE V inhibitor.
Negative_regulation (inhibitor) of PDE III
1) Confidence 0.10 Published 2003 Journal Eur J Anaesthesiol Section Abstract Doc Link 12650491 Disease Relevance 0.17 Pain Relevance 0
Inhibition of PDE-3, which metabolizes cAMP, is another option for the treatment of pulmonary hypertension.
Negative_regulation (Inhibition) of PDE-3 associated with hypertension
2) Confidence 0.03 Published 2009 Journal Pediatr Surg Int Section Body Doc Link PMC2734260 Disease Relevance 0.88 Pain Relevance 0
Milrinone, a PDE-3 inhibitor, was found to decrease the pulmonary artery pressure and pulmonary resistance in animals.
Negative_regulation (inhibitor) of PDE-3 in pulmonary artery
3) Confidence 0.03 Published 2009 Journal Pediatr Surg Int Section Body Doc Link PMC2734260 Disease Relevance 0.84 Pain Relevance 0
In addition, microinjection of the selective PDE III inhibitor Ro 20-1724 into the rat brain stem has been shown to produce analgesia.
Negative_regulation (microinjection) of PDE III in brain stem associated with analgesia
4) Confidence 0.03 Published 1985 Journal J. Med. Chem. Section Abstract Doc Link 2985781 Disease Relevance 0.36 Pain Relevance 0.28
In addition, microinjection of the selective PDE III inhibitor Ro 20-1724 into the rat brain stem has been shown to produce analgesia.
Negative_regulation (microinjection) of PDE III in brain stem associated with analgesia
5) Confidence 0.03 Published 1985 Journal J. Med. Chem. Section Abstract Doc Link 2985781 Disease Relevance 0.36 Pain Relevance 0.28
Cilostazol, a reversible, selective inhibitor of PDE III with antiplatelet, antithrombotic and vasodilatory effects, was approved by the FDA in 1999 for the treatment of Intermittent Claudication.
Negative_regulation (inhibitor) of PDE III associated with increased venous pressure under development
6) Confidence 0.01 Published 2007 Journal Recent patents on cardiovascular drug discovery Section Abstract Doc Link 18221117 Disease Relevance 1.05 Pain Relevance 0.27

General Comments

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