INT328422

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.67 Pain Relevance 0

lysosome (Neu1, Dnase2b) extracellular region (Dnase2b) hydrolase activity, acting on glycosyl bonds (Neu1) plasma membrane (Neu1) DNA metabolic process (Dnase2b) cytoplasm (Dnase2b)

Anatomy Link Frequency lens 2 Neu1 (Mus musculus) Dnase2b (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 2 5.00 ketamine 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 1 99.16 Cataract 48 97.44 Aging 4 16.32 Aids-related Complex 9 5.00 Stress 2 5.00 Sprains And Strains 1 5.00 Burns 1 5.00 Alopecia 1 5.00 Dislocations 1 5.00 Congenital Anomalies 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Importantly, the degradation of DNA in differentiating lens fibers requires the lysosomal enzyme, DNase II beta (DLAD), and in DLAD knock out mice nuclei are not degraded, resulting in lens opacity and cataract formation [10,11,69-71].

Protein_catabolism (degradation) of lysosomal enzyme in lens Positive_regulation (requires) of DNase II beta associated with targeted disruption and cataract

1) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.67 Pain Relevance 0

General Comments

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