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Context Info
Confidence 0.75
First Reported 1978
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 50
Total Number 54
Disease Relevance 23.69
Pain Relevance 8.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cellular_component (Gpt) biological_process (Gpt)
cytoplasm (Gpt)
Anatomy Link Frequency
liver 10
plasma 4
blood 2
poly 2
colon 1
Gpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 51 100.00 Very High Very High Very High
Glutamate 44 100.00 Very High Very High Very High
Gabapentin 4 99.74 Very High Very High Very High
headache 4 99.72 Very High Very High Very High
Paracetamol 194 99.56 Very High Very High Very High
ischemia 20 99.12 Very High Very High Very High
neuralgia 1 98.40 Very High Very High Very High
corticosteroid 1 96.00 Very High Very High Very High
alcohol 12 95.28 Very High Very High Very High
anesthesia 18 94.04 High High
Disease Link Frequency Relevance Heat
Headache Disorders 2 100.00 Very High Very High Very High
Injury 211 99.98 Very High Very High Very High
Hematuria 2 99.70 Very High Very High Very High
Urological Neuroanatomy 21 99.62 Very High Very High Very High
Proteinuria 2 99.48 Very High Very High Very High
Hepatotoxicity 173 99.46 Very High Very High Very High
Leukocytosis 2 99.22 Very High Very High Very High
Cv Unclassified Under Development 23 99.12 Very High Very High Very High
Headache 2 99.08 Very High Very High Very High
Obesity 34 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male C57BL/6 mice injected intraperitoneally (i.p.) with various doses of PAP were sacrificed at 12 hours for measurement of serum glutamic-pyruvic transaminase (GPT) and sorbitol dehydrogenase (SDH) levels and determination of the extent of hepatic nonprotein sulfhydryl (NPSH) and glutathione (GSH) depletion.
Gene_expression (levels) of GPT
1) Confidence 0.75 Published 2001 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 11170313 Disease Relevance 0.47 Pain Relevance 0.56
OBJECTIVE: To compare efficacy and safety of gabapentin (GPT) versus placebo for prophylaxis of chronic daily headache (CDH) (headache at least 15 days/month of greater than 4 hours duration over preceding 6 months).
Gene_expression (prophylaxis) of GPT associated with headache disorders, headache and gabapentin
2) Confidence 0.67 Published 2003 Journal Neurology Section Abstract Doc Link 14694042 Disease Relevance 0.27 Pain Relevance 0.45
Hepatoprotective activity was monitored by estimating the serum transaminases (GOT and GPT), alkaline phosphatase and bilirubin in serum, hepatic triglycerides, and by histopathological changes in the livers of experimental rats.
Gene_expression (estimating) of GPT in livers
3) Confidence 0.65 Published 1990 Journal Indian J. Med. Res. Section Abstract Doc Link 2228075 Disease Relevance 0.25 Pain Relevance 0.24
Serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) were estimated by International Federation of Clinical Chemistry.15 Serum bilirubin was estimated by Diazo method.16
Gene_expression (estimated) of alanine aminotransferase
4) Confidence 0.65 Published 2008 Journal Indian Journal of Nephrology Section Body Doc Link PMC2813123 Disease Relevance 0.24 Pain Relevance 0.05
Physical signs, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), total protein, and albumin were normal in all groups throughout the treatment period (data not shown).
Gene_expression (signs) of GPT
5) Confidence 0.65 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2809233 Disease Relevance 0.17 Pain Relevance 0
 ; (IL-6): interleukin-6; (ROS): reactive oxygen species; (PARP): poly (ADP-ribose) polymerase; (NO2/NO3): Nitrite/nitrate; (MPO): Myeloperoxidase activity; (ALT): alanine aminotransferase; (AST): aspartate aminotransferase; (iNOS): inducible nitric oxide.


Gene_expression (activity) of alanine aminotransferase in poly associated with urological neuroanatomy
6) Confidence 0.65 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.93 Pain Relevance 0.08
 ; (IL-6): interleukin-6; (ROS): reactive oxygen species; (PARP): poly (ADP-ribose) polymerase; (NO2/NO3): Nitrite/nitrate; (MPO): Myeloperoxidase activity; (ALT): alanine aminotransferase; (AST): aspartate aminotransferase; (iNOS): inducible nitric oxide.


Gene_expression (oxide) of alanine aminotransferase in poly associated with urological neuroanatomy
7) Confidence 0.65 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.93 Pain Relevance 0.08
In contrast, treatment with AAP + PYP produced levels of caspase-3 activity, DNA fragmentation, GSH and GOT/GPT that matched the values seen in the control group.
Gene_expression (produced) of GPT
8) Confidence 0.65 Published 2008 Journal Phytother Res Section Abstract Doc Link 18729249 Disease Relevance 0.41 Pain Relevance 0.07
To improve the diagnostic value of the ALT assay and to understand the molecular basis for serum ALT changes in various pathophysiological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), examined their tissue expressions at the messenger RNA and protein levels, and determined ALT1 and ALT 2 serum levels in response to liver damage in rodents.
Spec (examined) Gene_expression (expressions) of ALT1 in liver associated with hepatotoxicity
9) Confidence 0.63 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.84 Pain Relevance 0
To improve the diagnostic value of the ALT assay and to understand the molecular basis for serum ALT changes in various pathophysiological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), examined their tissue expressions at the messenger RNA and protein levels, and determined ALT1 and ALT 2 serum levels in response to liver damage in rodents.
Gene_expression (isoenzyme) of ALT1 in liver associated with hepatotoxicity
10) Confidence 0.63 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.84 Pain Relevance 0
To improve the diagnostic value of the ALT assay and to understand the molecular basis for serum ALT changes in various pathophysiological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), examined their tissue expressions at the messenger RNA and protein levels, and determined ALT1 and ALT 2 serum levels in response to liver damage in rodents.
Gene_expression (cloned) of ALT1 in liver associated with hepatotoxicity
11) Confidence 0.63 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.85 Pain Relevance 0
In addition, ALT isoenzymes distribute differentially at the subcellular level in that ALT1 is a cytoplasmic protein and ALT2 a mitochondrial protein, supporting bioinformatic prediction of mitochondrial localization of ALT2.
Gene_expression (protein) of ALT1
12) Confidence 0.63 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.52 Pain Relevance 0.08
Conclusion: Using animal models of hepatoxicity induced by carbon tetrachloride and acetaminophen, we found that both serum ALT1 and ALT2 protein levels were significantly elevated and correlated with ALT activity, providing, for the first time, the molecular basis for the elevated total serum ALT activity.
Gene_expression (levels) of ALT1 associated with paracetamol
13) Confidence 0.63 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.22 Pain Relevance 0.10
Animals fed corn oil and/or low protein levels showed significant increases in both GOT and GPT levels (Fig. 1).
Gene_expression (levels) of GPT
14) Confidence 0.61 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.56 Pain Relevance 0.39
Plasma GOT and GPT levels increased significantly after acute intoxication with acetaminophen.
Gene_expression (levels) of GPT in Plasma associated with paracetamol and poisoning
15) Confidence 0.61 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.52 Pain Relevance 0.23
In 2003, we established gpt delta rats in a Sprague-Dawley (SD) background by introducing ?
Gene_expression (rats) of gpt
16) Confidence 0.60 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.36 Pain Relevance 0
This gpt delta rat carries approximately five copies of ?
Gene_expression (rat) of gpt
17) Confidence 0.60 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.34 Pain Relevance 0
Levels of amylase, lipase, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubine and alkaline phosphatase were measured by a veterinary clinical laboratory using standard laboratory techniques.
Gene_expression (Levels) of alanine aminotransferase
18) Confidence 0.58 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.26 Pain Relevance 0.07
Quantitative real-time polymerase chain reaction (qRT-PCR) analysis shows that ALT1 messenger RNA is widely distributed and mainly expressed in intestine, liver, fat tissues, colon, muscle, and heart, in the order of high to low expression level, whereas ALT2 gene expression is more restricted, mainly in liver, muscle, brain, and white adipose tissue.
Gene_expression (expressed) of ALT1 in colon associated with obesity
19) Confidence 0.56 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.80 Pain Relevance 0
The tissue distribution pattern of ALT1 and ALT2 proteins largely agrees with their messenger RNA expression.
Gene_expression (pattern) of ALT1
20) Confidence 0.56 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.71 Pain Relevance 0.06

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