INT329144

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 5.79
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LGI1) extracellular space (LGI1) extracellular region (LGI1)
Anatomy Link Frequency
brain 2
neuronal 1
neurons 1
embryonic kidney 1
cerebellum 1
LGI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 913 99.52 Very High Very High Very High
Hippocampus 77 92.24 High High
hyperexcitability 22 89.76 High High
Sciatic nerve 44 74.80 Quite High
Multiple sclerosis 11 72.68 Quite High
Pyramidal cell 22 30.16 Quite Low
Pain 44 5.00 Very Low Very Low Very Low
Neuropathic pain 22 5.00 Very Low Very Low Very Low
imagery 22 5.00 Very Low Very Low Very Low
Central nervous system 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 66 100.00 Very High Very High Very High
Neuroblastoma 11 98.76 Very High Very High Very High
Syndrome 484 96.04 Very High Very High Very High
Cancer 209 93.48 High High
Limbic Encephalitis 297 91.60 High High
Epilepsy 176 89.76 High High
Cognitive Disorder 22 87.84 High High
Disease 33 79.68 Quite High
Isaacs Syndrome 275 79.36 Quite High
Thymoma 77 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, only a few patients had antibodies binding to the Kv1 subunits themselves but most bound only to one of two proteins, leucine-rich glioma inactivated 1 (Lgi1) or contactin-associated protein-2 (Caspr2), that are part of the ?
inactivated 1 Binding (bound) of associated with glioma
1) Confidence 0.38 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.54 Pain Relevance 0.15
Five sera bound to contactin-2 itself but four of these sera also bound to Kv1, Caspr2 or Lgi1.


Lgi1 Binding (bound) of
2) Confidence 0.34 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.39 Pain Relevance 0.14
Surprisingly, only a few patients had antibodies binding to the Kv1 subunits themselves but most bound only to one of two proteins, leucine-rich glioma inactivated 1 (Lgi1) or contactin-associated protein-2 (Caspr2), that are part of the ?
Lgi1 Binding (bound) of associated with glioma
3) Confidence 0.34 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.55 Pain Relevance 0.15
Here, we show that the majority of VGKC-antibodies of high titre are not directed towards the Kv1 subunits themselves but to two proteins, Lgi1 and Caspr2, that are closely associated with VGKCs in brain tissue and remain complexed with the VGKCs in 2% digitonin extracts.
Lgi1 Binding (associated) of in brain associated with potassium channel
4) Confidence 0.33 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.15 Pain Relevance 0.13
In contrast, Serum 1 (B) binds to the mf more than the rad, colocalizing with Lgi1.
Lgi1 Binding (binds) of
5) Confidence 0.33 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.31 Pain Relevance 0.17
This was explained by the fact that Lgi1 is secreted from neurons and can then bind to cell surfaces, as shown in neuroblastoma and COS7 cells (Sirerol-Piquer et al., 2006) and now demonstrated in HEK293 cells.
Lgi1 Binding (bind) of in neurons associated with neuroblastoma
6) Confidence 0.33 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.54 Pain Relevance 0.11
Lgi1 associates specifically with Kv1.1 subunits in CNS presynaptic terminals (Schulte et al., 2006), and is a secreted protein that can associate with neuronal and non-neuronal cell membranes (Sireol-Piquer et al., 2006).
Lgi1 Binding (associate) of in neuronal
7) Confidence 0.33 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.30 Pain Relevance 0.30
Here, we show that the majority of VGKC-antibodies of high titre are not directed towards the Kv1 subunits themselves but to two proteins, Lgi1 and Caspr2, that are closely associated with VGKCs in brain tissue and remain complexed with the VGKCs in 2% digitonin extracts.
Lgi1 Binding (complexed) of in brain associated with potassium channel
8) Confidence 0.33 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.18 Pain Relevance 0.13
Lgi1 binds ADAM22 on CNS postsynaptic membranes (Fukata et al., 2006; Ogawa et al., 2010) but we could not detect ADAM22 in our human embryonic kidney cell cultures (data not shown); further Lgi1 receptors are being identified and might be responsible for our findings (Sagane et al., 2008).
Lgi1 Binding (binds) of in embryonic kidney
9) Confidence 0.33 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.50 Pain Relevance 0.06
In the cerebellum, Serum 6 (C) colocalizes with Caspr2 in the molecular (mol) and granule cell layers (GCL), but does not bind to the pinceau where Lgi1 is strongly expressed (red arrows in D) but Caspr2 is absent.
Lgi1 Neg (not) Binding (bind) of in cerebellum
10) Confidence 0.33 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.28 Pain Relevance 0.11
To confirm that the Lgi1 binding was related to VGKC-antibodies, as defined by immunoprecipitation of 125I-?
Lgi1 Binding (binding) of associated with potassium channel
11) Confidence 0.33 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.05 Pain Relevance 0.15

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