INT329184

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.75
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (FLG) cytoplasmic membrane-bounded vesicle (FLG)
Anatomy Link Frequency
epidermis 1
FLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 64.96 Quite High
cytokine 9 62.64 Quite High
chemokine 7 61.76 Quite High
Inflammatory response 3 31.24 Quite Low
psoriasis 22 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dermatitis 31 99.16 Very High Very High Very High
Disease 20 76.72 Quite High
INFLAMMATION 22 64.96 Quite High
Contact Dermatitis 9 48.24 Quite Low
Increased Venous Pressure Under Development 1 26.52 Quite Low
Psoriasis 40 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Skin Diseases 3 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Filaggrin deficiency in the epidermis of AD patients is reasonably implicated in different, not yet clearly defined, aspects of CE malfunction in these subjects, including poor CE hydration and decreased generation of filaggrin acidic metabolites such as transurocanic acid, with consequent uncontrolled activation of serine proteases [70].
Negative_regulation (deficiency) of Filaggrin in epidermis associated with dermatitis
1) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.75 Pain Relevance 0.12

General Comments

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