INT32920

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Context Info
Confidence 0.71
First Reported 1985
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 4.24
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Msx1) nucleus (Msx1) DNA binding (Msx1)
Anatomy Link Frequency
embryos 2
DA neurons 1
brain 1
nucleus 1
midbrain 1
Msx1 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 106 100.00 Very High Very High Very High
Inflammation 50 100.00 Very High Very High Very High
cytokine 8 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Dopamine 422 99.56 Very High Very High Very High
melanocortin 1 receptor 35 97.80 Very High Very High Very High
Central nervous system 105 95.32 Very High Very High Very High
Inflammatory response 6 84.48 Quite High
agonist 90 83.52 Quite High
Thalamus 14 81.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 55 100.00 Very High Very High Very High
Adhesions 15 97.92 Very High Very High Very High
Obesity 399 97.56 Very High Very High Very High
Appetite Loss 70 93.88 High High
Aggression 4 92.76 High High
Congenital Anomalies 24 91.08 High High
Hyperphagia 21 84.64 Quite High
Syndrome 24 83.48 Quite High
Arthritis 2 83.48 Quite High
Peritonitis 1 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicate that forced expression of Spry1 in Wnt1-Cre expressing cells results in reduced domains of Msx1 and Msx2 expression in craniofacial structures, while expression in the limb buds remains intact albeit at a reduced level.
Gene_expression (expression) of Msx1 in limb buds
1) Confidence 0.71 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.15 Pain Relevance 0
We next examined the expression of Msx1 and Msx2 in Spry1;Wnt1-Cre embryos.
Spec (examined) Gene_expression (expression) of Msx1 in embryos
2) Confidence 0.71 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.21 Pain Relevance 0
Spry1;Wnt1-Cre embryos also exhibit a complete absence of the frontal bone; therefore we surmised that Msx1 and Msx2 expression would be reduced or absent.
Neg (absent) Gene_expression (expression) of Msx1 in frontal bone
3) Confidence 0.71 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.14 Pain Relevance 0
The resident mice were given either a single acute injection of MSH (MSH); 0.9% NaCl to drink (for 48 h prior to testing; SAL); a combination of both treatments (MSH + SAL) or an injection of 0.9% physiological saline (control group; CON).
Gene_expression (injection) of MSH
4) Confidence 0.67 Published 1985 Journal Behav. Brain Res. Section Abstract Doc Link 2988581 Disease Relevance 0.17 Pain Relevance 0
The resident mice were given either a single acute injection of MSH (MSH); 0.9% NaCl to drink (for 48 h prior to testing; SAL); a combination of both treatments (MSH + SAL) or an injection of 0.9% physiological saline (control group; CON).
Gene_expression (injection) of MSH
5) Confidence 0.67 Published 1985 Journal Behav. Brain Res. Section Abstract Doc Link 2988581 Disease Relevance 0.17 Pain Relevance 0
-MSH produced remarkable inhibition, between 50–70% of both cell adhesion and cell emigration, whereas it did not affect the responses observed in MC3R-null mice.
Gene_expression (produced) of MSH associated with adhesions
6) Confidence 0.65 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.62 Pain Relevance 0.30
Here we show that ultraviolet light potently induces expression of MSH in keratinocytes, but fails to stimulate pigmentation in the absence of functional MC1R in red/blonde-haired Mc1r(e/e) mice.
Gene_expression (expression) of MSH in pigmentation associated with melanocortin 1 receptor
7) Confidence 0.60 Published 2006 Journal Nature Section Abstract Doc Link 16988713 Disease Relevance 0.12 Pain Relevance 0.58
The survival of the BG02 hESC line under these conditions was very limited as compared to that of the BG01V2 and BG03 cell lines, and treatment of BG02-derived EBs with SPIE did not result in expression of Msx1.
Gene_expression (expression) of Msx1
8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.27
Cells in the central, denser areas of colonies were relatively undifferentiated at this time, as illustrated by expression of the midbrain progenitor marker Msx1 (Fig. 3G).
Gene_expression (expression) of Msx1 in midbrain associated with midbrain
9) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.13
To determine whether the cultures induced by these factors contained mesencephalic-restricted neural progenitor cells or DA neurons, analysis of Msx1 and TH expression was carried out after 10 days.
Gene_expression (expression) of Msx1 in DA neurons associated with dopamine
10) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.13
Of note, expression of Msx1 was not found in either in the treated or the control condition for BG02 cells.
Gene_expression (expression) of Msx1
11) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.03
The results indicated that embryos that successfully generated pregnancies and successful fetuses displayed up-regulated expression of genes necessary for implantation (COX2, CDX2), carbohydrate metabolism (ALOX15), growth factor (BMP15), signal transduction (PLAU) and placental development (PLAC8), while embryos that failed to generate a pregnancy overexpressed inflammatory cytokines (TNF), protein amino acid binding (EEF1A1), transcription factors (MSX1, PTTG1) and glucose metabolism genes (El-Sayed et al., 2006).
Gene_expression (expression) of MSX1 in embryos associated with inflammation, cox2 and cytokine
12) Confidence 0.33 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.15 Pain Relevance 0.15
Exclusion of PTN or IGF2 decreased the percentage of colonies containing Msx1-expressing cells from 48%, to 17% and 10%, respectively.
Gene_expression (expressing) of Msx1
13) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.12
ASIP-YY displaces NDP-MSH from human melanocortin receptors expressed on HEK-293 human kidney cells, and inhibits ?
Gene_expression (displaces) of MSH in kidney
14) Confidence 0.14 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.08
For example, in hypothalamic explant experiments injection of MCH into the hypothalamus increased the production of NPY and AgRP and decreased the production of MSH and CART, as measured by radioimmunoassay [153].


Gene_expression (production) of MSH in hypothalamus
15) Confidence 0.07 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.14 Pain Relevance 0.18
-MSH may be the important POMC product in inhibiting feeding centrally in humans [41], but not rodents, as rodents do not produce ?
Gene_expression (product) of MSH
16) Confidence 0.06 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.67 Pain Relevance 0.08
-MSH has a higher affinity for the MC4R than ?
Gene_expression (has) of MSH
17) Confidence 0.06 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.24 Pain Relevance 0
-MSH and is found widely in the brain [125].
Gene_expression (found) of MSH in brain
18) Confidence 0.05 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.29 Pain Relevance 0
-MSH is not produced physiologically in rodents [7,120] and so any observed effects could be through pharmacological activation of the MC4R?
Neg (not) Gene_expression (produced) of MSH
19) Confidence 0.05 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.47 Pain Relevance 0.06
2-MSH is rather surprising, given the presence of the MC4R and the absence of the MC3R in this nucleus (Table 3; [42]).
Gene_expression (presence) of MSH in nucleus
20) Confidence 0.05 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0 Pain Relevance 0.11

General Comments

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