INT32923

Context Info Confidence 0.57 First Reported 1984 Last Reported 1985 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 0 Pain Relevance 2.38

signal transduction (TRIM13) endoplasmic reticulum (TRIM13) intracellular (TRIM13) ligase activity (TRIM13) cytoplasm (TRIM13) signal transducer activity (TRIM13)

TRIM13 (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 13 100.00 agonist 5 100.00 Morphine 6 99.84 antagonist 1 95.56 opiate 8 94.76 Opioid 7 91.60

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Displacement curve analyses demonstrated that GTP and its nonhydrolyzable analog, GPP(NH)P, inhibited the binding of [3H]dihydromorphine (mu agonist), [3H]D-Ala2-D-Leu5-enkephalin (delta agonist), and [3H]ethylketocyclazocine (general agonist) but not [3H]diprenorphine (general antagonist).

Negative_regulation (inhibited) of Leu5 Binding (binding) of associated with antagonist, agonist and enkephalin

1) Confidence 0.57 Published 1985 Journal Brain Res. Bull. Section Abstract Doc Link 2988712 Disease Relevance 0 Pain Relevance 0.41

Similarly, morphine (1 nM) inhibited the higher-affinity binding of 3H-D-Ala2-D-Leu5-enkephalin to a greater extent than its lower-affinity binding component, consistent with a common high-affinity binding site for opiates and enkephalins.

Negative_regulation (inhibited) of Leu5 Binding (binding) of associated with opiate, enkephalin and morphine

2) Confidence 0.57 Published 1984 Journal Mol. Pharmacol. Section Abstract Doc Link 6323950 Disease Relevance 0 Pain Relevance 0.87

Both treatments also eliminated the ability of low morphine concentrations (less than 1 nM) to inhibit 3H-D-Ala2-D-Leu5-enkephalin binding and of low D-Ala2-D-Leu5-enkephalin concentrations (less than 1 nM) to inhibit [3H]dihydromorphine binding.

Negative_regulation (inhibit) of Leu5 Binding (binding) of associated with enkephalin and morphine

3) Confidence 0.42 Published 1984 Journal Mol. Pharmacol. Section Abstract Doc Link 6323950 Disease Relevance 0 Pain Relevance 1.10

General Comments

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