INT329448

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Revision as of 20:44, 20 September 2012 by Daniel (Talk | contribs)

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL17A, Vegfa) extracellular region (IL17A, Vegfa) cell differentiation (Vegfa)
cytoplasm (Vegfa) cell-cell signaling (IL17A) cell proliferation (Vegfa)
Anatomy Link Frequency
fibroblasts 2
IL17A (Homo sapiens)
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 81 99.28 Very High Very High Very High
cytokine 13 94.28 High High
Inflammation 22 93.24 High High
antagonist 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 75 99.28 Very High Very High Very High
INFLAMMATION 25 93.24 High High
Pressure And Volume Under Development 1 52.24 Quite High
Synovitis 12 39.68 Quite Low
Disease 38 36.20 Quite Low
Arthritis 3 5.00 Very Low Very Low Very Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Experimental Arthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some RA synovial fibroblasts spontaneously produced VEGF-A, however VEGF-A production was significantly increased by rIL-17 even at low concentrations (1 ng/ml). rIL-17 at higher concentrations also significantly induced IL-6 secretion by RA synovial fibroblasts, a cytokine involved in both inflammation and angiogenesis (reviewed in [27]).
rIL-17 Positive_regulation (increased) of Gene_expression (produced) of VEGF in fibroblasts associated with inflammation, cytokine and arthritis
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.59 Pain Relevance 0.32

General Comments

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