INT329680

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (BMI1, CDKN2A) nucleolus (BMI1, CDKN2A) nucleus (BMI1, CDKN2A)
nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
BMI1 (Homo sapiens)
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 18 100.00 Very High Very High Very High
Lifespan 4 100.00 Very High Very High Very High
Cancer 31 99.80 Very High Very High Very High
Breast Cancer 1 96.40 Very High Very High Very High
Lymphatic System Cancer 2 87.76 High High
Hyperplasia 3 87.72 High High
Targeted Disruption 1 85.28 High High
Stomach Cancer 54 73.08 Quite High
Thyroid Neoplasm 1 50.32 Quite High
Adenocarcinoma 1 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that CBX7 shares some similarities in functions and mechanisms with Bmi-1 including inhibiting cellular senescence and extending the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus [17,20,21].
Bmi-1 Negative_regulation (downregulating) of Gene_expression (expression) of INK4a associated with aging, cancer and lifespan
1) Confidence 0.15 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.14 Pain Relevance 0

General Comments

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