INT329794

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.05 Pain Relevance 0.44

cytoplasm (TLR2, IL12A) extracellular space (IL12A) signal transduction (TLR2) extracellular region (IL12A) plasma membrane (TLR2) intracellular (TLR2)

Anatomy Link Frequency Immune cells 2 TLR2 (Homo sapiens) IL12A (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 24 99.96 Inflammatory response 1 97.28 chemokine 6 92.12 Inflammation 29 88.52 Neuropeptide 1 80.16 cINOD 1 51.80 psoriasis 19 46.92 agonist 7 39.04 corticosteroid 2 6.72 antagonist 3 5.00

Disease Link Frequency Relevance Heat Acne 11 99.58 INFLAMMATION 30 97.28 Adhesions 1 91.12 Psoriasis 27 46.92 Dermatitis 28 11.96 Skin Diseases 6 11.04 Skin Cancer 29 5.00 Disease 14 5.00 Cancer 8 5.00 Infection 4 5.00

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Protein

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Anatomy

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Immune cells such as TLR 2 expressing macrophages (perifollicular and peribulbar) tend to surround pilosebaceous follicles in acne lesions; subsequent TLR 2 triggering due to P. acnes results in IL-6, IL-8, and IL-12 cytokine production [4].

TLR 2 Positive_regulation (triggering) of Positive_regulation (results) of IL-12 in Immune cells associated with acne and cytokine

1) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.05 Pain Relevance 0.44

General Comments

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