INT330088
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Once active, Rac-GTP associates with the membrane and interacts with the tetratricopeptide repeat (TPR) site on p67phox subunit [13] and with membrane bound NOX2, resulting in NADPH oxidase complex activation [14], [15]. | |||||||||||||||
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To investigate the role of NOX2 NADPH oxidase, we utilized a specific competitive NOX2 inhibitor, gp91ds-tat, which is a 9 amino acid peptide sequence of the p47Phox docking site on NOX2 and prevents p47phox from forming a complex with NOX2 [22]. | |||||||||||||||
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General Comments
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