INT330088

Context Info Confidence 0.26 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.70 Pain Relevance 0.31

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)

Cybb (Rattus norvegicus)

Pain Link Frequency Relevance Heat Intracerebroventricular 4 87.52 Hippocampus 34 75.44 ischemia 172 73.16 anesthesia 8 65.36 cerebral cortex 4 63.76 Pyramidal cell 6 5.00 isoflurane 6 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Stress 52 83.08 Cv Unclassified Under Development 60 73.16 Stroke 16 72.80 Targeted Disruption 4 71.08 Apoptosis 12 69.60 Death 38 67.56 Injury 6 64.68 Cv General 4 Under Development 110 50.00 Cognitive Disorder 24 50.00 Reperfusion Injury 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Once active, Rac-GTP associates with the membrane and interacts with the tetratricopeptide repeat (TPR) site on p67phox subunit [13] and with membrane bound NOX2, resulting in NADPH oxidase complex activation [14], [15].

NOX2 Binding (bound) of

1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.56 Pain Relevance 0.13

To investigate the role of NOX2 NADPH oxidase, we utilized a specific competitive NOX2 inhibitor, gp91ds-tat, which is a 9 amino acid peptide sequence of the p47Phox docking site on NOX2 and prevents p47phox from forming a complex with NOX2 [22].

NOX2 Binding (complex) of

2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.14 Pain Relevance 0.18

General Comments

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