INT330105

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.47
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Rac1, Mapk8) mitochondrion (Mapk8) intracellular (Rac1)
enzyme binding (Rac1) GTPase activity (Rac1) cytosol (Mapk8)
Anatomy Link Frequency
neuronal 1
Rac1 (Rattus norvegicus)
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 86 99.72 Very High Very High Very High
Hippocampus 17 15.88 Low Low
cerebral cortex 2 5.64 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 30 99.72 Very High Very High Very High
Stress 26 99.34 Very High Very High Very High
Apoptosis 6 97.44 Very High Very High Very High
Death 19 96.48 Very High Very High Very High
Cognitive Disorder 12 93.44 High High
Cv General 4 Under Development 55 91.64 High High
Reperfusion Injury 6 77.44 Quite High
Stroke 8 43.60 Quite Low
Targeted Disruption 2 9.88 Low Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in addition to enhancing NADPH oxidase activation and oxidative stress following ischemia/reperfusion, Rac1 also enhances proapototic JNK signaling, which collectively can enhance oxidative damage and apoptotic neuronal cell death in the hippocampal CA1 region, leading to hippocampal dysfunction and cognitive decline.
Rac1 Positive_regulation (enhances) of JNK in neuronal associated with stress, cognitive disorder, ischemia, apoptosis and death
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.47 Pain Relevance 0.34

General Comments

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