INT330108

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.86 Pain Relevance 0.46

intracellular (Racgap1, Cybb) cytoplasm (Racgap1, Cybb) cell differentiation (Racgap1) mitochondrion (Cybb) transport (Racgap1) Golgi apparatus (Cybb)

Racgap1 (Mus musculus) Cybb (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 86 97.96 Hippocampus 17 96.72 Pyramidal cell 3 91.60 cerebral cortex 2 64.08 anesthesia 4 5.00 isoflurane 3 5.00 Intracerebroventricular 2 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Cv General 4 Under Development 55 97.96 Death 19 95.96 Cv Unclassified Under Development 30 92.48 Stress 26 73.48 Targeted Disruption 2 55.04 Pressure And Volume Under Development 1 51.44 Brain Hemorrhage 1 50.88 Cognitive Disorder 12 50.00 Reperfusion Injury 6 36.76 Stroke 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Studies in phagocytic cells have shown that Rac1 GTPase plays a key role in activation of the NOX2 NADPH oxidase isoform by a direct binding and recruiting of the p67phox subunit to the membrane [13], [30].

GTPase Positive_regulation (activation) of NOX2

1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.86 Pain Relevance 0.46

General Comments

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