INT33013

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Context Info
Confidence 0.50
First Reported 1982
Last Reported 1993
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0
Pain Relevance 3.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
jejunum 2
brain 2
amygdala 2
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 20 100.00 Very High Very High Very High
agonist 9 100.00 Very High Very High Very High
Clonidine 23 99.98 Very High Very High Very High
antagonist 6 99.84 Very High Very High Very High
amygdala 6 98.80 Very High Very High Very High
Serotonin 3 98.40 Very High Very High Very High
cerebral cortex 3 89.56 High High
Hippocampus 6 86.76 High High
Action potential 1 80.56 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose that the alpha-2 adrenoceptors in the amygdala/pyriform region contribute to the prophylactic effects of systemically administered clonidine and that the facilitation of kindling observed after systemic administration of alpha-2 antagonists may be due to blockade of alpha-2 adrenoceptors outside of the amygdala/pyriform region.
Spec (may) Positive_regulation (due) of Negative_regulation (blockade) of alpha-2 in amygdala associated with antagonist, amygdala and clonidine
1) Confidence 0.50 Published 1993 Journal Brain Res. Section Abstract Doc Link 7908598 Disease Relevance 0 Pain Relevance 0.67
It can be concluded that chronic clonidine administration can induce down-regulation of both the alpha 2 presynaptic autoreceptors located on noradrenaline terminals and the alpha 2 presynaptic heteroreceptors located on serotonin terminals.
Positive_regulation (induce) of Negative_regulation (down-regulation) of alpha 2 associated with noradrenaline, serotonin and clonidine
2) Confidence 0.50 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990964 Disease Relevance 0 Pain Relevance 0.67
It can be concluded that chronic clonidine administration can induce down-regulation of both the alpha 2 presynaptic autoreceptors located on noradrenaline terminals and the alpha 2 presynaptic heteroreceptors located on serotonin terminals.
Positive_regulation (induce) of Negative_regulation (down-regulation) of alpha 2 associated with noradrenaline, serotonin and clonidine
3) Confidence 0.50 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990964 Disease Relevance 0 Pain Relevance 0.66
Chronic clonidine induces functional down-regulation of presynaptic alpha 2-adrenoceptors regulating [3H]noradrenaline and [3H]5-hydroxytryptamine release in the rat brain.
Positive_regulation (induces) of Negative_regulation (down-regulation) of alpha 2 in brain associated with noradrenaline and clonidine
4) Confidence 0.43 Published 1985 Journal Eur. J. Pharmacol. Section Title Doc Link 2990964 Disease Relevance 0 Pain Relevance 0.65
Alpha-2 adrenergic inhibition of intestinal secretion induced by prostaglandin E1, vasoactive intestinal peptide and dibutyryl cyclic AMP in rat jejunum.
Positive_regulation (induced) of Negative_regulation (inhibition) of Alpha-2 in jejunum
5) Confidence 0.04 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6121049 Disease Relevance 0 Pain Relevance 0.46
The inhibitory effect of the alpha 2-agonist was distinctly diminished in the presence of 30 mmol/l TEA but was restored in low Ca2+/high Mg2+ buffer.
Positive_regulation (restored) of Negative_regulation (effect) of alpha 2-agonist associated with agonist
6) Confidence 0.02 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8383299 Disease Relevance 0 Pain Relevance 0.87

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