INT33035

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Context Info
Confidence 0.30
First Reported 1985
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.56
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Stmn1) cytosol (Stmn1) cytoskeleton (Stmn1)
intracellular (Stmn1) cytoplasm (Stmn1)
Anatomy Link Frequency
nerve 1
Stmn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 11 100.00 Very High Very High Very High
Kappa opioid receptor 2 100.00 Very High Very High Very High
Peripheral nervous system 1 99.60 Very High Very High Very High
agonist 7 99.58 Very High Very High Very High
fortral 6 98.76 Very High Very High Very High
Opioid 6 98.56 Very High Very High Very High
Analgesic 15 97.28 Very High Very High Very High
Clonidine 4 97.08 Very High Very High Very High
Root ganglion neuron 2 95.24 Very High Very High Very High
Morphine 3 94.84 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 1 99.00 Very High Very High Very High
Ganglion Cysts 2 94.92 High High
Disease 1 90.28 High High
Injury 1 75.36 Quite High
Pain 9 63.20 Quite High
Substance Withdrawal Syndrome 1 57.60 Quite High
Drug Dependence 4 44.80 Quite Low
INFLAMMATION 4 36.80 Quite Low
Vomiting 4 25.00 Low Low
Dizziness 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes in opioid receptors (Op-R) caused by repeated administration of pentazocine and the effect of concomitant clonidine were investigated.
Positive_regulation (caused) of Op-R associated with fortral, opioid receptor and clonidine
1) Confidence 0.30 Published 1985 Journal Acta Med. Okayama Section Abstract Doc Link 2992233 Disease Relevance 0.06 Pain Relevance 1.05
We used activating transcription factor 3 (ATF3) and growth-associated phosphoprotein (GAP-43) as markers for nerve injury and axonal regeneration, respectively.
Positive_regulation (activating) of growth-associated phosphoprotein in nerve associated with nervous system injury
2) Confidence 0.05 Published 2006 Journal Auton Neurosci Section Abstract Doc Link 16716760 Disease Relevance 0.50 Pain Relevance 0.35
Several in vitro and in vivo studies have shown that DHE is a selective mu-opioid receptor (OP(3)) agonist that also binds and activates all human recombinant mu-, delta-, and kappa-opioid receptors (OP(3), OP(1), and OP(2)).
Positive_regulation (activates) of OP associated with kappa opioid receptor, agonist and opioid receptor
3) Confidence 0.02 Published 2002 Journal CNS Drug Rev Section Abstract Doc Link 12481194 Disease Relevance 0 Pain Relevance 0.84
Several in vitro and in vivo studies have shown that DHE is a selective mu-opioid receptor (OP(3)) agonist that also binds and activates all human recombinant mu-, delta-, and kappa-opioid receptors (OP(3), OP(1), and OP(2)).
Positive_regulation (activates) of OP associated with kappa opioid receptor, agonist and opioid receptor
4) Confidence 0.02 Published 2002 Journal CNS Drug Rev Section Abstract Doc Link 12481194 Disease Relevance 0 Pain Relevance 0.83
Contrary to opioid peptides which strikly require Tyr in position 1, the active core that activates the OP4 appears to be towards the centre of the peptide molecule and includes Phe4.
Positive_regulation (activates) of OP4 associated with opioid
5) Confidence 0.01 Published 1999 Journal Farmaco Section Abstract Doc Link 10668183 Disease Relevance 0 Pain Relevance 1.17

General Comments

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