INT330379

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.95 Pain Relevance 1.18

response to stress (IL10, MAPK14) nucleoplasm (MAPK14) intracellular (IL10) cytoplasm (MAPK14) cell-cell signaling (IL10) cytosol (MAPK14)

IL10 (Homo sapiens) MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat IPN 3 99.86 cytokine 42 95.08 Inflammation 12 90.76 Dorsal horn 2 89.68 Spinal cord 4 88.40 Neuropathic pain 2 87.92 Opioid 3 86.80 Chronic pancreatitis 1 71.80 Pain 16 68.32 Enkephalin 6 39.64

Disease Link Frequency Relevance Heat Cold Sores 367 100.00 Inflammatory Pain 3 99.86 Cancer 202 96.28 Necrosis 2 96.00 INFLAMMATION 15 90.76 Neuropathic Pain 7 87.92 Generalized Anxiety Disorder 2 84.64 Pancreatitis 2 71.80 Diabetes Mellitus 10 70.00 Pain 20 68.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mata and colleagues have demonstrated, in a rat model of inflammatory pain, that expression of IL-10 by a HSV-1 vector in DRG prevents activation of p38 mitogen-activated protein kynase (p38 MAPK) and expression of full-length membrane-spanning tumour necrosis factor-?

Gene_expression (expression) of IL-10 Negative_regulation (prevents) of Positive_regulation (activation) of p38 associated with necrosis, cold sores, cancer and ipn

1) Confidence 0.00 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.95 Pain Relevance 1.18

General Comments

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