INT331193

Context Info Confidence 0.17 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.73 Pain Relevance 0

peptidase activity (Atxn3) nucleus (Atxn3) cytoplasm (Atxn3)

Atxn3 (Mus musculus)

Pain Link Frequency Relevance Heat carbamazepine 1 5.00 Clonidine 1 5.00 Substantia nigra 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Toxicity 9 99.12 Frontotemporal Dementia 3 95.72 Parkinson's Disease 9 94.28 Spinocerebellar Ataxia Type 2 1 92.44 Alzheimer's Dementia 18 59.36 Disease 15 52.96 Neurodegenerative Disease 16 42.32 Apoptosis 5 31.60 Starvation 6 5.00 Multiple Sulfatase Deficiency Disease 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CCI-779, a rapamycin ester (i.e., an analogue of rapamycin) reduces both mutant huntingtin and ataxin-3 levels, thereby attenuating toxicity in mouse models of HD and SCA3, respectively [68,69].

Negative_regulation (reduces) of Gene_expression (levels) of ataxin-3 associated with toxicity

1) Confidence 0.17 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.73 Pain Relevance 0

General Comments

This test has worked.