INT331563

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Apcs) extracellular region (Apcs) cell adhesion (Cd4)
plasma membrane (Cd4) protein complex assembly (Apcs) enzyme binding (Cd4)
Anatomy Link Frequency
MR1 1
T cell 1
Cd4 (Mus musculus)
Apcs (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 15 50.00 Quite Low
cytokine 9 12.08 Low Low
Inflammation 15 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Glutamate receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 31 91.08 High High
Immunization 6 81.28 Quite High
Diabetes Mellitus 14 75.04 Quite High
Sprains And Strains 6 43.44 Quite Low
Lymphopenia 18 34.84 Quite Low
Autoimmune Disease 17 17.04 Low Low
Multiple Sclerosis 3 15.40 Low Low
Demyelinating Disease 3 15.24 Low Low
Disease 13 12.92 Low Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although peptide fragments can bind cell surface MHC molecules directly and elicit T cell immune responses, presentation of native Ag by APCs to CD4+ T cells in vivo usually requires processing, which involves proteolytic degradation of protein within APCs and association of peptide cleavage products with MHC II molecules [19], [20].
CD4 Binding (presentation) of APCs in T cell
1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.28 Pain Relevance 0
Since the MR1 mAb targets the interaction between CD4+ T cells and APCs, we next analyzed its effect on transferred HNT CD4+ T cells.
CD4 Spec (analyzed) Binding (interaction) of APCs in MR1
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.08 Pain Relevance 0

General Comments

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