INT331796

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.88 Pain Relevance 0.08

cytoplasm (Akt1, Pik3r1) cytosol (Akt1, Pik3r1) signal transduction (Akt1, Pik3r1) nucleus (Akt1, Pik3r1) plasma membrane (Akt1, Pik3r1) kinase activity (Akt1, Pik3r1)

Akt1 (Mus musculus) Pik3r1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 55 95.76 dexamethasone 1 55.48 Inflammatory response 24 18.08 cINOD 3 5.00 chemokine 2 5.00 cytokine 1 5.00 withdrawal 1 5.00 Inflammatory marker 1 5.00 metalloproteinase 1 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat Chronic Obstructive Pulmonary Disease 108 98.68 INFLAMMATION 82 95.76 Nicotine Addiction 10 90.24 Stress 15 86.28 Asthma 11 61.48 Disease 33 23.76 Apoptosis 8 5.00 Death 5 5.00 Bronchitis 4 5.00 Pneumonia 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

/Akt signaling pathway restores and protects both HDAC-2 activity and GC function in oxidant-mediated GC-insensitive models.55 Similarly, selective inhibition of PI3K?

Akt Negative_regulation (protects) of Negative_regulation (inhibition) of PI3K

1) Confidence 0.04 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.88 Pain Relevance 0.08

General Comments

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