INT331897

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE5A, Pde5a) signal transduction (PDE5A, Pde5a) cellular_component (PDE5A)
PDE5A (Homo sapiens)
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 1 68.88 Quite High
headache 5 19.60 Low Low
backache 4 5.00 Very Low Very Low Very Low
nud 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Onset of action 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erectile Dysfunction 70 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 6 89.60 High High
Headache 5 19.60 Low Low
Lower Urinary Tract Symptoms 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Low Back Pain 4 5.00 Very Low Very Low Very Low
Dyspepsia 4 5.00 Very Low Very Low Very Low
Myalgia 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the United States, 3 PDE5Is are currently available; sildenafil (Viagra®, Pfizer), vardenafil (Levitra®, Bayer), and tadalafil (Cialis®, Lilly-ICOS).7 Each of these drugs is highly efficacious in the management of ED although pharmacokinetic and side-effect profiles differ and results for each drug may vary for individual men.7,8 Another PDE5I, udenafil, has been approved for use in South Korea, and a number of novel PDE5Is are currently in various stages of development.9,10
PDE5I Binding (vary) of PDE5Is associated with erectile dysfunction
1) Confidence 0.02 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2939761 Disease Relevance 0.64 Pain Relevance 0.03

General Comments

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