INT331941

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 4.57
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Tymp)
Tymp (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 6 90.08 High High
agonist 120 85.92 High High
Angina 6 68.32 Quite High
Bile 36 50.00 Quite Low
antagonist 6 26.32 Quite Low
palliative 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 81 99.84 Very High Very High Very High
Cancer 150 99.78 Very High Very High Very High
Biliary Cancer 60 98.16 Very High Very High Very High
Klatskin's Tumor 84 93.64 High High
Cholangiocarcinoma 6 90.60 High High
Stress 96 90.00 High High
Disease 21 89.60 High High
Pancreatic Cancer 3 85.72 High High
Stomach Cancer 3 84.84 Quite High
Apoptosis 21 79.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, we examined the expression of TP and ERCC1 associated with the response to 5-FU and cisplatin chemotherapy [15].
TP Spec (examined) Binding (associated) of
1) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.24 Pain Relevance 0
Among the 66 patients who received adjuvant treatment, there was no significant difference in TTR and OS associated with TP and ERCC1 expression (p = 0.212, 0.322 for TP; p = 0.591, 0.794 for ERCC1).


TP Binding (associated) of associated with recurrence
2) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.44 Pain Relevance 0
For all tumors, positive TP and p53 staining was associated with an advanced stage compared to tumors with negative staining (p = 0.027 and p = 0.009, respectively).
TP Binding (associated) of associated with cancer
3) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.23 Pain Relevance 0
Regulation of TP signaling itself is similarly complex, with multiple kinase-mediated pathways implicated in receptor desensitization, while oligomerization of the distinct TP splice variant products has also been implicated in modulating function [8], [9].
TP Binding (oligomerization) of
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.51 Pain Relevance 0.15
These observations suggest that H2O2 exposure results in an alteration to the TP?
TP Binding (alteration) of
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0
While it is possible that hydrogen peroxide affects calcium mobilization through a mechanism independent of the TP?
TP Binding (independent) of
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0.04
TP receptor polyclonal antibody, which recognizes both TP?
TP Binding (recognizes) of
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.07 Pain Relevance 0.03
Similarly, intracellular HA-TP?
TP Binding (intracellular) of
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0
stabilization at the cell-surface remains to be understood, and while clearly an important aspect of TP?
TP Binding (aspect) of
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.07 Pain Relevance 0.15

General Comments

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