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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.05
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PPARG, Ins1) nucleoplasm (PPARG) carbohydrate metabolic process (Ins1)
enzyme binding (PPARG) DNA binding (PPARG) lipid metabolic process (PPARG)
Anatomy Link Frequency
muscle 1
PPARG (Homo sapiens)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 5 90.76 High High
tolerance 7 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 10 98.28 Very High Very High Very High
Diabetes Mellitus 95 93.96 High High
INFLAMMATION 5 90.76 High High
Hyperglycemia 11 88.12 High High
Dyslipidemia /

Combined Dyslipidemia

2 87.84 High High
Hypersensitivity 1 72.48 Quite High
Insulin Resistance 16 65.04 Quite High
Atherosclerosis 10 51.36 Quite High
Hyperinsulinism 1 38.00 Quite Low
Hypoglycemia 29 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pioglitazone is a potent insulin sensitizer, which binds to the peroxisome-proliferator activated receptor-gamma, resulting in enhanced muscle, liver, and adipose tissue sensitivity to insulin, with a resultant decline in fasting and postprandial plasma glucose levels.43–45 Pioglitazone also augments beta cell function46 (Figure 3), reduces inflammation,47 improves endothelial dysfunction,48,49 corrects diabetic dyslipidemia,50 and improves the defect in insulin signaling in muscle, leading to impaired glucose transport/metabolism results in increased generation of nitric oxide (NO).
peroxisome-proliferator activated receptor-gamma Binding (binds) of insulin in muscle associated with inflammation, diabetes mellitus and obesity
1) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.96 Pain Relevance 0.05

General Comments

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