INT332689

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.71 Pain Relevance 0.14

cell differentiation (Ros1) cell proliferation (Ros1) extracellular space (Edn1) extracellular region (Edn1) plasma membrane (Ros1) cell-cell signaling (Edn1)

Anatomy Link Frequency vasculature 1 Edn1 (Rattus norvegicus) Ros1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcium channel 2 98.58 Kinase C 10 95.70 Bioavailability 5 92.56 Inflammation 5 24.72 antagonist 7 15.04 cva 3 5.00 Migraine 2 5.00 aspirin 1 5.00 cytokine 1 5.00 fibrosis 1 5.00

Disease Link Frequency Relevance Heat Coronary Heart Disease 1 94.44 Diabetes Complications 3 93.98 Diabetes Mellitus 29 89.96 Parkinson's Disease 1 65.96 Hyperglycemia 9 60.36 Stress 15 56.64 Congenital Anomalies 12 49.36 Insulin Resistance 3 45.96 Uterine Fibroids 1 35.12 Disease 2 33.72

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In diabetes, ET-1 levels are elevated and upregulation of ETA and ETB occurs in the vasculature, along with a reduction in NO bioavailability.1,4 Activated ET receptors can also be found in diabetic complications such as cardiomyopathy and testopathy.24–26 NOX is stimulated mainly by ETA, with PKC actively involved.27 The vasoconstrictive activity of ET-1 is mediated by the activity of NOX, and an activation of the L-type calcium channels by ET-1 causes an influx of calcium ions through activating NOX.28 An interaction of ET-1 with ROS is known as the ET–ROS pathway, which activates the ERK signaling pathway and AP-1 transcriptional factor.29 There is a positive feedback mechanism between them via an activation of ERK.

ET-1 Binding (interaction) of ROS in vasculature associated with kinase c, diabetes complications, diabetes mellitus, calcium channel, coronary heart disease and bioavailability

1) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.71 Pain Relevance 0.14

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