INT333041

Context Info Confidence 0.44 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.07

plasma membrane (AGTR1) signal transducer activity (AGTR1)

AGTR1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 3 80.96 TRP channel 7 5.00 potassium channel 1 5.00 Central nervous system 1 5.00 Neuropathic pain 1 5.00 Peripheral nervous system 1 5.00 Inflammation 1 5.00 Catecholamine 1 5.00

Disease Link Frequency Relevance Heat Stress 4 5.00 Apoptosis 3 5.00 Increased Venous Pressure Under Development 3 5.00 Coronary Heart Disease 1 5.00 Hypesthesia 1 5.00 Disease 1 5.00 Neuropathic Pain 1 5.00 INFLAMMATION 1 5.00 Channelopathies 1 5.00 Myocardial Infarction 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These observations reveal for the first time that activation of AT1aR can trigger internalization and functional down-regulation of TRPV4, and the data uncover an entirely novel functional attribute for the heterodimerization between AT1aR and TRPV4.

Regulation (regulation) of Positive_regulation (activation) of AT1aR

1) Confidence 0.44 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.07

General Comments

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