INT333071

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 22.70
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HNRNPA1) transport (HNRNPA1) mRNA processing (HNRNPA1)
nucleolus (HNRNPA1) RNA binding (HNRNPA1) nucleus (HNRNPA1)
Anatomy Link Frequency
neuronal 3
blood 1
gray matters 1
neurons 1
astrocytes 1
HNRNPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 52 99.68 Very High Very High Very High
cytokine 143 99.16 Very High Very High Very High
chemokine 91 95.84 Very High Very High Very High
Neurobehavioral 91 87.20 High High
Inflammatory response 26 32.88 Quite Low
Central nervous system 39 5.00 Very Low Very Low Very Low
glial activation 26 5.00 Very Low Very Low Very Low
ketamine 13 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
Multiple sclerosis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 2457 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 156 100.00 Very High Very High Very High
INFLAMMATION 78 99.68 Very High Very High Very High
Injury 143 99.56 Very High Very High Very High
Infection 442 98.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 949 98.52 Very High Very High Very High
Death 65 95.16 Very High Very High Very High
Cancer 39 94.00 High High
Necrosis 39 93.52 High High
Targeted Disruption 156 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct exposure of HCV core protein to primary human neurons suppressed the neuronal autophagy, leading to neurite retraction.
Gene_expression (exposure) of core protein in neurite associated with hepatitis c virus infection
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.74 Pain Relevance 0.04
Direct or indirect exposure of HCV core protein results in neuronal injury
Gene_expression (exposure) of core protein in neuronal associated with injury and hepatitis c virus infection
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.06 Pain Relevance 0.12
To determine if HCV core protein exerted its neurotoxic effects indirectly through induction of neurotoxic factors secreted by microglia or astrocytes, supernatants from HFAs or HFµ?
Gene_expression (exerted) of core protein in astrocytes associated with hepatitis c virus infection
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.14 Pain Relevance 0.03
HIV-1 infection and Vpr protein potentiate the neuroimmune activation and neurotoxic effects of HCV core protein
Gene_expression (effects) of core protein associated with acquired immune deficiency syndrome or hiv infection, hepatitis c virus infection and infection
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.95 Pain Relevance 0.13
HCV core protein alters neuronal membrane response and suppresses neuronal autophagy
Gene_expression (alters) of core protein in neuronal associated with hepatitis c virus infection
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.33 Pain Relevance 0
In addition, soluble HIV-1 Vpr protein at a subneurotoxic concentration (50 nM) together with HCV core protein (10 and 100 nM) caused significantly increased HFN injury (Figure 6C) indicated by reduced ?
Gene_expression (caused) of core protein associated with injury, acquired immune deficiency syndrome or hiv infection and hepatitis c virus infection
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 2.43 Pain Relevance 0.23
HCV core protein neurotoxicity and interleukin-6 induction were potentiated by HIV-1 Vpr protein (p<0.05).
Gene_expression (neurotoxicity) of core protein associated with drug induced neurotoxicity, acquired immune deficiency syndrome or hiv infection and hepatitis c virus infection
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943470 Disease Relevance 2.37 Pain Relevance 0.20
HCV core protein exposure induced expression of pro-inflammatory cytokines including interleukin-1?
Gene_expression (expression) of core protein associated with inflammation, hepatitis c virus infection and cytokine
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943470 Disease Relevance 2.52 Pain Relevance 0.19
Recombinant HCV core protein fused to ?
Gene_expression (fused) of core protein associated with hepatitis c virus infection
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.55 Pain Relevance 0.11
HCV core protein exposure was not toxic to astrocytes (Figure 4A) while the highest concentration of HCV core protein (100 nM) was cytotoxic to neurons, indicated by the loss of ?
Gene_expression (exposure) of core protein in neurons associated with hepatitis c virus infection
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.01 Pain Relevance 0.06
HCV core protein modulated neuronal membrane currents and reduced both ?
Gene_expression (modulated) of core protein in neuronal associated with hepatitis c virus infection
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943470 Disease Relevance 2.56 Pain Relevance 0.21
Given HCV core protein has been detected in white and gray matters [9], its cytotoxic effects on HFAs and HFNs were investigated.
Gene_expression (detected) of core protein in gray matters associated with hepatitis c virus infection
12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.02 Pain Relevance 0.07
The most abundantly expressed HCV protein, core, is released and soluble in blood as a part of HCV morphogenesis [27] and serum levels of HCV core protein ranges from pg/ml to ng/ml [28].
Gene_expression (levels) of core protein in blood associated with hepatitis c virus infection
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 2.02 Pain Relevance 0.11

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