INT333291

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.13
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DDC) small molecule metabolic process (DDC) lyase activity (DDC)
cellular nitrogen compound metabolic process (DDC) cellular amino acid metabolic process (DDC) cytoplasm (DDC)
Anatomy Link Frequency
neurons 4
serotonergic neurons 2
DDC (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 99 99.80 Very High Very High Very High
monoamine 6 97.96 Very High Very High Very High
Raphe 12 95.36 Very High Very High Very High
primary somatosensory cortex 3 10.00 Low Low
fluoxetine 30 5.00 Very Low Very Low Very Low
Thalamus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Handedness 36 67.24 Quite High
Ganglion Cysts 9 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Vibrio Infection 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.
Positive_regulation (required) of Gene_expression (express) of dopa decarboxylase in neurons associated with serotonin and monoamine
1) Confidence 0.49 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.39
The transcription factor Pet1 is expressed in serotonergic neurons and directly activates the transcription of genes that are involved in the synthesis (Tph and Aadc) and uptake (Sert) of serotonin.
Positive_regulation (activates) of Gene_expression (synthesis) of Aadc in serotonergic neurons associated with serotonin
2) Confidence 0.49 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.57
These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.
Positive_regulation (required) of Gene_expression (express) of Aadc in neurons associated with serotonin and monoamine
3) Confidence 0.49 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.39

General Comments

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