INT333304

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.10
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) cell differentiation (Zic2)
transport (Slc6a4) plasma membrane (Slc6a4) nucleus (Zic2)
Anatomy Link Frequency
retina 4
eye 2
Zic2 (Mus musculus)
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Raphe 20 65.44 Quite High
Serotonin 165 64.24 Quite High
monoamine 10 42.48 Quite Low
fluoxetine 50 5.00 Very Low Very Low Very Low
primary somatosensory cortex 5 5.00 Very Low Very Low Very Low
Thalamus 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Handedness 60 95.12 Very High Very High Very High
Adhesions 5 17.08 Low Low
Ganglion Cysts 15 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Vibrio Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we assessed whether Zic2 is sufficient to induce Sert expression in vivo.
Zic2 Positive_regulation (induce) of Gene_expression (expression) of Sert
1) Confidence 0.68 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
In this study, we show that the transcription factor Zic2 has an important function in controlling eye-specific refinement in the SC by inducing the expression of Sert specifically in iRGCs.
Zic2 Positive_regulation (inducing) of Gene_expression (expression) of Sert in eye
2) Confidence 0.68 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.10 Pain Relevance 0.06
Zic2 is necessary and sufficient to induce the expression of Sert
Zic2 Positive_regulation (induce) of Gene_expression (expression) of Sert
3) Confidence 0.68 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Together, these results indicate that, in vivo, Zic2 is necessary and sufficient to induce Sert expression in the mouse retina.


Zic2 Positive_regulation (induce) of Gene_expression (expression) of Sert in retina
4) Confidence 0.68 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
To further test whether Zic2 is required for Sert expression in the VT region of the retina, we examined Sert mRNA levels in Zic2 hypomorphic mutant mice (Zic2kd/kd).
Zic2 Positive_regulation (required) of Gene_expression (expression) of Sert in retina
5) Confidence 0.45 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0

General Comments

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