INT333511

Context Info Confidence 0.10 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.49 Pain Relevance 0.12

plasma membrane (GYPE) cytoplasm (STON1)

Anatomy Link Frequency thalamus 1 STON1 (Homo sapiens) GYPE (Homo sapiens)

Pain Link Frequency Relevance Heat Thalamus 31 98.08 Dopamine 8 84.92 deep brain stimulation 57 24.64 Action potential 6 5.00 Substantia nigra 4 5.00 Neurotransmitter 3 5.00 palliative 2 5.00 imagery 2 5.00 Spinal cord 1 5.00 midbrain 1 5.00

Disease Link Frequency Relevance Heat Disease 70 95.40 Parkinson's Disease 26 92.32 Convulsion 2 47.76 Tremor 10 5.00 Hypokinesia 5 5.00 Cognitive Disorder 3 5.00 Epilepsy 2 5.00 Burns 2 5.00 Brain Disease 2 5.00 Dyskinesias 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this static model, a decrease in inhibition to the striatum led to an increased activity of the STN, which increased excitation to the GPe and GPi, which increased the inhibition to the thalamus.

STN Positive_regulation (increased) of GPe in thalamus associated with thalamus

1) Confidence 0.10 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.49 Pain Relevance 0.12

General Comments

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