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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TBK1) plasma membrane (TBK1) cytoplasm (TBK1)
TBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 71 96.48 Very High Very High Very High
cINOD 34 95.80 Very High Very High Very High
aspirin 9 87.88 High High
cytokine 9 87.08 High High
addiction 1 85.60 High High
metalloproteinase 3 73.00 Quite High
Pain 22 71.20 Quite High
cva 3 24.20 Low Low
qutenza 8 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 75 96.48 Very High Very High Very High
Targeted Disruption 4 93.12 High High
Arthropathy 2 76.60 Quite High
Pain 22 71.20 Quite High
Injury 7 60.28 Quite High
Sprains And Strains 17 49.92 Quite Low
Cv General 3 Under Development 3 24.20 Low Low
Coagulation Disorder 2 19.48 Low Low
Disease 26 14.40 Low Low
Urinary Tract Infection 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IRF3-P responses to r-ceramide were reduced by the TLR4 and TRAM siRNAs but were less affected by suppression of TBK1 expression.
Negative_regulation (suppression) of Gene_expression (expression) of TBK1
1) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.09 Pain Relevance 0.04
Immunosuppressant drugs also reduce nuclear expression of NF-kB.[397075] Research now indicates that blocking the activation of NF-kB along with other inflammation mediators [Table 2] is the major mechanism for reducing inflammation by natural compounds.

Negative_regulation (reduce) of Gene_expression (expression) of NF-kB associated with inflammation
2) Confidence 0.04 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.81 Pain Relevance 0.62

General Comments

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