INT333608

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.92
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF3) nucleoplasm (IRF3) plasma membrane (IRF3)
nucleus (IRF3) DNA binding (IRF3) cytoplasm (IRF3)
IRF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 2 56.20 Quite High
agonist 2 31.44 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 30 99.68 Very High Very High Very High
Disease Susceptibility 4 98.72 Very High Very High Very High
Infection 54 97.76 Very High Very High Very High
Systemic Lupus Erythematosus 6 93.72 High High
Pyelonephritis 60 90.32 High High
Urinary Tract Infection 64 89.60 High High
Bacterial Infection 4 85.36 High High
Bacterial Respiratory Disease 8 83.76 Quite High
Abscess 14 71.00 Quite High
Renal Disease 6 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IRF3 promoter activity was reduced by the disease-associated genotype, consistent with the pathology in Irf3?
Negative_regulation (reduced) of IRF3 associated with disease
1) Confidence 0.38 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2944801 Disease Relevance 0.75 Pain Relevance 0
The effect of the Irf3 deletion on disease susceptibility in mice suggested, however, that risk might be associated with reduced, rather than increased, IRF3 function.
Negative_regulation (reduced) of IRF3 associated with disease susceptibility
2) Confidence 0.38 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 1.17 Pain Relevance 0.03

General Comments

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