INT333690

Context Info Confidence 0.23 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0

DNA binding (Hr, Trp53) nucleus (Hr, Trp53) nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53) enzyme binding (Trp53)

Hr (Mus musculus) Trp53 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 1 5.00 Pain 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 78 77.32 Targeted Disruption 29 65.48 Huntington's Chorea 1 56.32 Injury 2 53.32 Death 8 15.12 Stress 10 14.00 Necrosis 4 7.28 Urological Neuroanatomy 3 5.00 Alopecia 2 5.00 Hypoxia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Another possibility is that Hr represses transcription of p53 through a mechanism involving HDAC1and a nuclear receptor.

Hr Negative_regulation (represses) of Transcription (transcription) of p53

1) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.51 Pain Relevance 0

General Comments

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