INT333907

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.07
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HDAC1) nucleoplasm (HDAC1) nucleolus (HDAC1)
nucleus (HDAC1) enzyme binding (HDAC1) transcription factor binding (HDAC1)
Anatomy Link Frequency
internal 1
HDAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 222 99.52 Very High Very High Very High
Osteoarthritis 108 98.72 Very High Very High Very High
Inflammation 75 90.16 High High
cytokine 15 86.00 High High
Inflammatory mediators 6 80.64 Quite High
Arthritis 15 41.28 Quite Low
corticosteroid 6 33.92 Quite Low
cINOD 13 5.00 Very Low Very Low Very Low
methotrexate 12 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 222 99.52 Very High Very High Very High
Frailty 114 98.72 Very High Very High Very High
Colon Cancer 53 95.64 Very High Very High Very High
Repression 9 91.84 High High
INFLAMMATION 92 90.16 High High
Disease 28 89.12 High High
Inflammatory Bowel Disease 3 76.08 Quite High
Systemic Lupus Erythematosus 3 74.48 Quite High
Cirrhosis 3 73.48 Quite High
Injury 8 71.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because HDAC1 and HDAC2 are localized mainly at the cell nuclei, we compared the nuclear protein levels of HDACs between RA and OA, with lamin A as an internal control, and showed a significant increase of HDAC1 protein in RA cells.
Positive_regulation (increase) of HDAC1 in internal associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.68 Pain Relevance 0.76
treatment tended to increase in HDAC1 (P = 0.0654; versus HDAC2, P = 0.049; versus HDAC3, P = 0.0354; versus HDAC8) (Figure 5c) (see Additional file 2).


Positive_regulation (increase) of HDAC1
2) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.59 Pain Relevance 0.14
When the relative mRNA expressions at 24 h after stimulation were compared among class I HDACs, the increase of mRNA in HDAC1 was significantly greater than that in other class I HDACs (P = 0.02).
Positive_regulation (increase) of HDAC1
3) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.25 Pain Relevance 0.13
In the silenced state, as in PPARG-negative HCT116 cells, the promoter is significantly enriched in HDAC1, MeCP2 and chromatin repressive marks such as H3K9me3 and H3K27me3.
Positive_regulation (enriched) of HDAC1
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.56 Pain Relevance 0

General Comments

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