INT33407

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Context Info
Confidence 0.34
First Reported 1986
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Naaladl1) plasma membrane (Naaladl1)
Anatomy Link Frequency
brain 1
Naaladl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diabetic neuropathy 4 99.20 Very High Very High Very High
Enkephalin 1 96.94 Very High Very High Very High
ischemia 2 95.56 Very High Very High Very High
Neuropathic pain 1 91.60 High High
opiate 2 88.88 High High
Glutamate 2 85.60 High High
Neuropeptide 1 80.36 Quite High
Serotonin 3 78.32 Quite High
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 4 99.20 Very High Very High Very High
Neuroblastoma 1 98.94 Very High Very High Very High
Diabetes Mellitus 2 98.00 Very High Very High Very High
Cv Unclassified Under Development 2 95.56 Very High Very High Very High
Neurological Disease 1 92.96 High High
Neuropathic Pain 1 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GCPII (NAALADase) inhibition prevents long-term diabetic neuropathy in type 1 diabetic BB/Wor rats.
Negative_regulation (inhibition) of NAALADase associated with diabetes mellitus and diabetic neuropathy
1) Confidence 0.34 Published 2002 Journal J. Neurol. Sci. Section Title Doc Link 11809162 Disease Relevance 0.74 Pain Relevance 0.48
Specific binding of [3H][D-Ala2,D-Leu5]enkephalin, [3H]ethylketocyclazocine, 5-[3H]hydroxytryptamine, and [3H]spiperone was examined in neuroblastoma-brain hybrid cell line NCB-20 following exposure to inhibitors of N-linked protein glycosylation (tunicamycin, TM) and oligosaccharide processing (swainsonine, SW).
Negative_regulation (inhibitors) of N-linked protein in brain associated with neuroblastoma and enkephalin
2) Confidence 0.00 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3004490 Disease Relevance 0.10 Pain Relevance 0.25

General Comments

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