INT334529

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.31 Pain Relevance 0.91

cell proliferation (Pax3) signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf) nucleus (Pax3) DNA binding (Pax3)

Anatomy Link Frequency peripheral nervous system 2 Pax3 (Mus musculus) Ngf (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 49 100.00 substance P 8 100.00 Peripheral nervous system 1 99.96 cytokine 2 99.80 antagonist 1 67.36 Antihistamine 2 59.20 Inflammation 7 5.00 qutenza 3 5.00 c fibre 3 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Eczema 108 94.14 Contact Dermatitis 1 87.84 Pruritus 24 42.48 Lichen 2 34.60 Papular Skin Disease 2 33.32 Erythema 3 33.00 INFLAMMATION 5 5.00 Congenital Anomalies 4 5.00 Disease 4 5.00 Hypersensitivity 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Also, we have already reported that olopatadine suppresses the increase of SP levels in the skin lesions induced by the repeated application of 2,4,6-trinitrochlorbenzane in DSNh of atopic model mouse.25 In AD patients, too, it has been reported that olopatadine significantly decreased the serum SP level because of down-modulatory effect on tachykinin release.26 Other studies have also shown that whereas NGF stimulates the synthesis and releases of SP in the central and peripheral nervous system, SP induces NGF synthesis via cytokines, too.27,28 These results suggest that the activations of NGF and SP are interdependent.

SP Positive_regulation (induces) of Gene_expression (synthesis) of NGF in peripheral nervous system associated with peripheral nervous system, nerve growth factor, eczema, cytokine and substance p

1) Confidence 0.03 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.31 Pain Relevance 0.91

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