INT335020

Context Info Confidence 0.62 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.82 Pain Relevance 0.18

cell differentiation (Fgf23) mitochondrion (Cyp24a1) extracellular space (Fgf23) oxidoreductase activity (Cyp24a1) extracellular region (Fgf23)

Anatomy Link Frequency kidney 2 Fgf23 (Mus musculus) Cyp24a1 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 48 80.72 agonist 3 56.64 cytokine 3 5.00 Spinal cord 3 5.00 sodium channel 3 5.00 Eae 3 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Disease 18 80.32 Obesity 51 79.84 Extrahepatic Cholestasis 3 74.56 Pancreatic Cancer 3 71.60 Targeted Disruption 111 56.08 Toxicity 3 53.60 Fatty Liver 15 31.36 Insulin Resistance 3 22.80 Weight Gain 3 8.24 Heart Defects 3 6.32

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The increased Fgf23 suppresses the expression of Cyp27b1 and induces the expression of Cyp24 by activating the ?

Fgf23 Positive_regulation (induces) of Gene_expression (expression) of Cyp24

1) Confidence 0.62 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.20 Pain Relevance 0.13

The Fgf23 suppresses the expression of Cyp27b1 and induces the expression of Cyp24 in the kidney (Shimada et al 2004).

Fgf23 Positive_regulation (induces) of Gene_expression (expression) of Cyp24 in kidney

2) Confidence 0.41 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.29 Pain Relevance 0.03

The suppression of Cyp27b1 expression and induction of Cyp24 expression by Fgf23 result in decreased levels of active vitamin D in serum.

Fgf23 Positive_regulation (induction) of Gene_expression (expression) of Cyp24

3) Confidence 0.41 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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