INT335738

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.88 Pain Relevance 0.06

transport (VCP) endoplasmic reticulum (VCP) cytoplasm (VCP) cytosol (VCP) lipid binding (VCP) cell death (VCP)

VCP (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 2 60.12 Eae 10 5.00 Hippocampus 8 5.00 imagery 6 5.00 cytokine 4 5.00 anesthesia 2 5.00 isoflurane 2 5.00 Neurotransmitter 2 5.00

Disease Link Frequency Relevance Heat Disease 54 96.80 Respiratory Failure 2 96.72 Muscle Weakness 34 94.76 Agraphia 2 92.04 Dyslexia 2 91.48 Apoptosis 48 90.12 Anomia 2 83.36 Frontotemporal Dementia 16 78.84 Dementia 6 76.68 Bone Disease 24 66.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Molecular genetic studies revealed that IBMPFD is caused by mutations in the Valosin Containing Protein (VCP) gene [7], and thus far 19 disease mutations have been identified (for review see [6], [14]).

Positive_regulation (caused) of IBMPFD associated with disease

1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 1.32 Pain Relevance 0.06

Most of these mutated residues causing IBMPFD are three-dimensionally located in close proximity and potentially interact with each other [26].

Positive_regulation (causing) of IBMPFD

2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.56 Pain Relevance 0

General Comments

This test has worked.