INT337100

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Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 21
Disease Relevance 45.04
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mgp) extracellular space (Mgp) extracellular region (Mgp)
endoplasmic reticulum (Mgp) protein complex assembly (Mgp) protein complex (Mgp)
Anatomy Link Frequency
vessels 5
plasma 1
plaques 1
basal ganglia 1
heart 1
Mgp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory marker 57 99.64 Very High Very High Very High
Inflammation 361 96.64 Very High Very High Very High
Dopamine 42 78.28 Quite High
agonist 6 77.28 Quite High
beta blocker 57 46.20 Quite Low
substance P 10 41.68 Quite Low
Dynorphin 6 40.72 Quite Low
Enkephalin 10 39.60 Quite Low
cocaine 10 37.44 Quite Low
cytokine 19 26.92 Quite Low
Disease Link Frequency Relevance Heat
Calcification 1767 100.00 Very High Very High Very High
Diabetes Mellitus 1349 99.96 Very High Very High Very High
Coronary Artery Disease 1444 99.92 Very High Very High Very High
INFLAMMATION 399 99.64 Very High Very High Very High
Atherosclerosis 361 99.48 Very High Very High Very High
Disorder Of Lipid Metabolism 171 97.88 Very High Very High Very High
Vascular Disease 19 94.56 High High
Carotid Artery Diseases 19 93.36 High High
Cardiovascular Disease 133 91.44 High High
Sclerosis 57 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is consistent with the high MGP mRNA expression observed in atherosclerotic vessels and plaques in patients with type 1 diabetes [9,13].
Gene_expression (expression) of MGP mRNA in plaques associated with calcification, diabetes mellitus and atherosclerosis
1) Confidence 0.71 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.90 Pain Relevance 0.04
Taken together, our and previous studies suggest that arterial calcification may lead to increased MGP expression, probably in a feedback attempt to reduce bone-like formation of calcium deposits in the vessel walls.
Gene_expression (expression) of MGP associated with calcification
2) Confidence 0.71 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.18 Pain Relevance 0.19
However, levels of MGP has been demonstrated to be high in calcified vessels, where MGP most probably is expressed as an inhibitory counteraction of the calcification process [6,23].
Gene_expression (levels) of MGP in vessels associated with calcification
3) Confidence 0.71 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.93 Pain Relevance 0.11
In healthy vessels MGP is synthesized at a low rate, probably because the need for calcification inhibition is low [9,23].
Gene_expression (synthesized) of MGP in vessels associated with calcification
4) Confidence 0.62 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 3.06 Pain Relevance 0.06
In individuals without compromised kidney function as in the present study, levels of circulating MGP depend primarily on the synthesis and secretion and clearance of MGP from VSMC and subsequent binding of MGP to calcified areas within the vascular wall.
Gene_expression (synthesis) of MGP in kidney associated with calcification
5) Confidence 0.62 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.73 Pain Relevance 0.04
In the present study we found that significantly more patients with IHD were treated with statins, so we cannot exclude that this has influenced the levels of MGP.
Gene_expression (levels) of MGP associated with calcification and coronary artery disease
6) Confidence 0.62 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.39 Pain Relevance 0.20
However, levels of MGP has been demonstrated to be high in calcified vessels, where MGP most probably is expressed as an inhibitory counteraction of the calcification process [6,23].
Gene_expression (expressed) of MGP in vessels associated with calcification
7) Confidence 0.62 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.82 Pain Relevance 0.12
In a multiple regression analyses there were however no association between MGP levels and statin use or LDL-levels, adjusting for significant covariates, but we do not now if MGP can be used as a biomarker or positive indicator for prognosis of IHD.
Gene_expression (levels) of MGP associated with calcification and coronary artery disease
8) Confidence 0.61 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.72 Pain Relevance 0.03
VSMCs grown in culture contain high levels of MGP, which is thought to limit the rate of calcification.
Gene_expression (levels) of MGP associated with calcification
9) Confidence 0.61 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 3.30 Pain Relevance 0
We found an additive effect of T2D and IHD on MGP levels, which has never been demonstrated previously.
Gene_expression (levels) of MGP associated with calcification, coronary artery disease and diabetes mellitus
10) Confidence 0.61 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.81 Pain Relevance 0.03
The present study is to our knowledge the first to compare MGP expression in patients with either T2D or IHD or both.
Gene_expression (expression) of MGP associated with calcification, coronary artery disease and diabetes mellitus
11) Confidence 0.55 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.01 Pain Relevance 0
In conclusion, in patients with T2D and IHD we found increased levels of plasma MGP which may indicate progressing media and intima calcification processes.
Gene_expression (levels) of MGP in plasma associated with calcification, coronary artery disease and diabetes mellitus
12) Confidence 0.55 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.61 Pain Relevance 0.04
Levels of MGP, YKL-40 and hsCRP were increased in patients with IHD and/or T2D (p < 0.0001) and patients with T2D and IHD had higher MGP levels (p < 0.001).
Gene_expression (Levels) of MGP associated with calcification, coronary artery disease and diabetes mellitus
13) Confidence 0.55 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3016330 Disease Relevance 2.74 Pain Relevance 0.12
In vessels from patients with diabetes, MGP levels are lower than in normal vessels, which suggest that reduced MGP in diabetes may predispose to calcification [24].
Gene_expression (levels) of MGP in vessels associated with calcification and diabetes mellitus
14) Confidence 0.54 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 3.06 Pain Relevance 0.10
We found that patients treated with statins had higher levels of MGP, and since we also found a positive correlation between HDL levels and MGP and a negative correlation between LDL levels and MGP, it could be speculated that higher MGP levels were an indication of better clinical and prognostic regulation of lipid levels due to statin treatment.
Gene_expression (levels) of MGP associated with calcification and disorder of lipid metabolism
15) Confidence 0.54 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.76 Pain Relevance 0.06
We found that patients treated with statins had higher levels of MGP, and since we also found a positive correlation between HDL levels and MGP and a negative correlation between LDL levels and MGP, it could be speculated that higher MGP levels were an indication of better clinical and prognostic regulation of lipid levels due to statin treatment.
Gene_expression (levels) of MGP associated with calcification and disorder of lipid metabolism
16) Confidence 0.54 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.76 Pain Relevance 0.12
Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease

Objective and design

Gene_expression (levels) of Matrix Gla Protein in heart associated with calcification, coronary artery disease, diabetes mellitus and inflammatory marker
17) Confidence 0.48 Published 2010 Journal Cardiovasc Diabetol Section Title Doc Link PMC3016330 Disease Relevance 2.40 Pain Relevance 0.14
Levels of MGP were significantly higher in patients treated with statins (2.32 ± 0.37 vs. 1.83 ± 0.41, p < 0.001) and ACE-inhibitors (2.36 ± 0.43 vs. 1.95 ± 0.43, p < 0.001) compared to non-treated.


Gene_expression (Levels) of MGP associated with calcification
18) Confidence 0.48 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.96 Pain Relevance 0
This last group was divided into Type IIa (projecting to the LGP, MGP, and SNr) and Type IIb (projecting to the LGP and SNr).
Gene_expression (projecting) of MGP
19) Confidence 0.39 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.05
According to the classical model of the basal ganglia, about half of the MSNs would project exclusively to the SNr/MGP, and the other half to the LGP (Alexander et al., 1990; DeLong, 1990).
Gene_expression (project) of MGP in basal ganglia
20) Confidence 0.39 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.14

General Comments

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