INT337811

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3b, Akt1) cytoplasm (Gsk3b, Akt1) cytosol (Gsk3b, Akt1)
nucleus (Gsk3b, Akt1) plasma membrane (Gsk3b, Akt1) kinase activity (Gsk3b, Akt1)
Gsk3b (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 22 66.24 Quite High
Dopamine 1 39.16 Quite Low
Pyramidal cell 1 16.00 Low Low
Kinase C 5 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 84 99.66 Very High Very High Very High
Sprains And Strains 1 72.96 Quite High
Manic Depressive Disorder 15 47.76 Quite Low
Cleidocranial Dysplasia 2 6.24 Low Low
Anxiety Disorder 16 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low
Depression 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KO mice are partly caused by the reduced phosphorylation levels of Akt and GSK3?.
Gene_expression (levels) of GSK3 Positive_regulation (caused) of Phosphorylation (phosphorylation) of Akt associated with targeted disruption
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.37 Pain Relevance 0.03

General Comments

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