INT337848

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Ros1, Mapk14) cell differentiation (Ros1) mitochondrion (Mapk14)
cell morphogenesis (Mapk14) response to stress (Mapk14) cytoplasm (Mapk14)
Ros1 (Mus musculus)
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 8 24.80 Low Low
imagery 7 11.48 Low Low
Eae 5 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
dorsal root ganglion 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
diabetic neuropathy 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 26 98.08 Very High Very High Very High
Hyperglycemia 55 94.24 High High
Diabetes Mellitus 13 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, the data indicate that phosphorylated p38 MAPK levels increase in association with ROS in hyperglycemic mice with increased oxidative stress and return to wildtype levels in SOD2-STZ mice that have reduced superoxide load despite hyperglycemia.
ROS Positive_regulation (increase) of Gene_expression (levels) of p38 MAPK associated with hyperglycemia and stress
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.27 Pain Relevance 0

General Comments

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