INT337883

From wiki-pain
Revision as of 06:13, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC3R) signal transducer activity (MC3R)
Anatomy Link Frequency
MC3 4
MC3R (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 12 99.04 Very High Very High Very High
agonist 20 81.16 Quite High
Central nervous system 6 67.80 Quite High
Neuropeptide 6 63.72 Quite High
tolerance 2 53.76 Quite High
antagonist 2 25.28 Quite Low
Intracerebroventricular 26 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 12 88.44 High High
Targeted Disruption 2 85.96 High High
Repression 4 54.96 Quite High
Impaired Glucose Tolerance 2 54.40 Quite High
Hyperphagia 4 47.52 Quite Low
Weight Loss 2 22.36 Low Low
Hypoglycemia 6 13.76 Low Low
Body Weight 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Hyperinsulinism 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo, the observed induction of COUP-TFII gene expression by the fed state could be therefore mediated indirectly by insulin through the conjunction of decreasing amount of AgRP and increasing amount of POMC leading downstream to an activation of the MC3/4-R.
Positive_regulation (increasing) of Positive_regulation (activation) of MC3 in MC3
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.05 Pain Relevance 0.14
These neurons are known to control food intake through the production of BDNF, a neurotrophin whose expression in the VMH is increased in response to the activation of MC3/4-R [24], [32], [33].
Positive_regulation (increased) of Positive_regulation (activation) of MC3 in MC3 associated with bdmf
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.32 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox