INT338044

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.38
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Pard3) cytoplasm (Pard3) lipid binding (Pard3)
extracellular space (F2) peptidase activity (F2) extracellular region (F2)
Anatomy Link Frequency
neurons 1
mast cell 1
F2 (Mus musculus)
Pard3 (Mus musculus)
Pain Link Frequency Relevance Heat
neuropeptide release 6 82.44 Quite High
nociceptor 48 72.40 Quite High
Inflammation 36 62.80 Quite High
Pain 18 61.44 Quite High
Calcitonin gene-related peptide 60 56.12 Quite High
Neuropeptide 36 55.60 Quite High
substance P 15 48.40 Quite Low
bradykinin 12 42.08 Quite Low
qutenza 42 39.96 Quite Low
imagery 21 30.88 Quite Low
Disease Link Frequency Relevance Heat
Injury 9 92.40 High High
INFLAMMATION 39 62.80 Quite High
Pain 18 61.44 Quite High
Nociception 63 57.32 Quite High
Neurogenic Inflammation 6 54.64 Quite High
Coagulation Disorder 6 18.88 Low Low
Hyperalgesia 9 9.76 Low Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Rupture 6 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional responses to thrombin, which should activate PAR3 (along with PAR1 and PAR4), are seen in a significantly lower number of neurons, however, suggesting that PAR3 is non-functional, at least when expressed in the absence of other PARs.
thrombin Positive_regulation (activate) of PAR3 in neurons
1) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.05 Pain Relevance 0.11
However, when thrombin or trypsin, both of which activate PAR3 along with PAR1/4, were used in a number of different studies of functional expression, responses were seen in a significantly smaller proportion of neurones than those suggested by histological data for PAR3.
thrombin Positive_regulation (activate) of PAR3
2) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.11 Pain Relevance 0.20
PAR1, PAR3, and PAR4 are activated by thrombin, reviewed in [5,6], while PAR2 is not activated by thrombin but is activated by trypsin and mast cell tryptase [7-9].
thrombin Positive_regulation (activated) of PAR3 in mast cell
3) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.22 Pain Relevance 0.09

General Comments

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