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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VAV3) plasma membrane (VAV3) cytoplasm (VAV3)
VAV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 2 82.52 Quite High
antagonist 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 98 98.00 Very High Very High Very High
Prostate Cancer 106 94.20 High High
Stomach Cancer 2 83.16 Quite High
Pulmonary Fibrosis 2 82.52 Quite High
Metastasis 36 67.12 Quite High
Hyperplasia 4 59.44 Quite High
Recurrence 4 53.60 Quite High
Apoptosis 16 51.28 Quite High
Disease 30 37.28 Quite Low
Bone Cancer 2 5.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In PC346DCC, activation of VAV3 and TWIST1 oncogenes and down-regulation of DKK3 tumor suppressor constitutes a possible mechanism for bypassing the AR pathway.
Positive_regulation (activation) of VAV3 associated with cancer
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.01 Pain Relevance 0.04
Src kinases are also activators of VAV3 and TWIST1, either directly by phosphorylating and releasing inhibitory tyrosine Y173 of VAV3, or indirectly by activating STAT3, a transcription activator for TWIST1 [58], [59].
Positive_regulation (activators) of VAV3
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.27 Pain Relevance 0

General Comments

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