INT338428

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.75 Pain Relevance 0.13

anatomical structure formation involved in morphogenesis (Gata3) cell morphogenesis (Gata3) DNA binding (Gata3) extracellular space (Il4) signal transduction (Gata3) extracellular region (Il4)

Il4 (Mus musculus) Gata3 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 45 94.08 Inflammation 26 88.60 fibrosis 3 20.16 chemokine 6 5.00 tolerance 3 5.00 Neuritis 1 5.00 Inflammatory response 1 5.00 Multiple sclerosis 1 5.00 Arthritis 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Asthma 104 99.40 Disease 14 93.08 INFLAMMATION 27 88.60 Hypersensitivity 24 78.88 Airway Remodeling 6 62.48 Eosinophilia 8 60.48 Fibrosis 3 20.16 Targeted Disruption 6 5.00 Occupational Lung Diseases 4 5.00 Hyperplasia 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IL-4 upregulates the fate-determining transcription factor GATA-3 in naïve T helper cells and is therefore essential for the initial differentiation and expansion of allergen-specific TH2 cells [3].

IL-4 Positive_regulation (upregulates) of GATA-3

1) Confidence 0.06 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.75 Pain Relevance 0.13

General Comments

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