INT33848

Context Info Confidence 0.36 First Reported 1986 Last Reported 2006 Negated 1 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 0.88 Pain Relevance 2.04

extracellular space (C6) extracellular region (C6) molecular_function (C6)

C6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 6 100.00 agonist 20 99.68 Bioavailability 1 98.20 local anesthetic 12 96.48 Morphine 2 70.56 Pain 4 5.00 Facet joint 3 5.00 Inflammation 2 5.00 Spinal cord 1 5.00 Sciatica 1 5.00

Disease Link Frequency Relevance Heat Hyperplasia 100 99.90 Disease 31 95.92 Osteoarthritis 53 88.76 Osteophyte 4 28.60 Hypertrophy 2 18.00 Sclerosis 3 15.96 Stress 5 5.00 Arthropathy 5 5.00 Injury 2 5.00 INFLAMMATION 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Esters synthesized link dopamine and L-dopa, by a succinyl linker, to C-3 position of glucose (I and II) and to C-6 of galactose (II and IV).

C-6 Binding (link) of associated with dopamine

1) Confidence 0.36 Published 2003 Journal J Drug Target Section Abstract Doc Link 12852438 Disease Relevance 0 Pain Relevance 0.33

Our initial assumption of achieving approximately the previously reported 46% prevalence of CPH was true for C5 and C6 but the actual prevalence at C3 and C4 was lower.

C6 Binding (true) of associated with hyperplasia

2) Confidence 0.03 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1592100 Disease Relevance 0.88 Pain Relevance 0

These findings show that C6SLMel binds to the allosterically coupled noncompetitive inhibitor site which is regulated by agonist binding.

C6SLMel Binding (binds) of associated with agonist

3) Confidence 0.01 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3018481 Disease Relevance 0 Pain Relevance 0.45

In addition, C6SLMel preferentially associates with the desensitized receptor state known to exhibit high affinities for agonists and local anesthetics.

C6SLMel Binding (associates) of associated with agonist and local anesthetic

4) Confidence 0.01 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3018481 Disease Relevance 0 Pain Relevance 0.47

At concentrations lower than 1 X 10(-5) M, C6SLMel does not bind to the agonist site but enhances [3H]acetylcholine binding.

C6SLMel Neg (not) Binding (bind) of associated with agonist

5) Confidence 0.01 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3018481 Disease Relevance 0 Pain Relevance 0.44

Furthermore, in the presence of carbamylcholine, back-titration of bound C6SLMel with phencyclidine decreases the highly immobilized component at concentrations consistent with the KD for phencyclidine.

C6SLMel Binding (bound) of

6) Confidence 0.01 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3018481 Disease Relevance 0 Pain Relevance 0.35

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