INT338872

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
neurite 2
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 1 76.92 Quite High
gABA 7 72.96 Quite High
bDMF 16 69.12 Quite High
Hippocampus 4 42.08 Quite Low
Glutamate receptor 3 15.52 Low Low
Lamotrigine 23 5.00 Very Low Very Low Very Low
depression 11 5.00 Very Low Very Low Very Low
carbamazepine 9 5.00 Very Low Very Low Very Low
anticonvulsant 8 5.00 Very Low Very Low Very Low
Gabapentin 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 4 100.00 Very High Very High Very High
Intellectual Impairment 1 97.84 Very High Very High Very High
Manic Depressive Disorder 125 80.56 Quite High
Thyroid Disease 1 35.20 Quite Low
Depression 14 5.00 Very Low Very Low Very Low
Recurrence 8 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 6 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Psychosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among their functions, miRNAs have been shown to regulate neurite outgrowth, neurogenesis and synaptic plasticity, mainly through the regulation of mediators such as CREB, methyl CpG binding protein 2 (MECP2), the fragile X mental retardation 1 protein (FMRP) and elements of the Wnt pathway [156].
Regulation (regulate) of Regulation (regulation) of CREB in neurite associated with intellectual impairment and neurodegenerative disease
1) Confidence 0.21 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.28 Pain Relevance 0.15

General Comments

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