INT33889

Context Info Confidence 0.41 First Reported 1986 Last Reported 1986 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.77 Pain Relevance 0.71

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)

pcp (Mus musculus) Oprk1 (Mus musculus)

Pain Link Frequency Relevance Heat Kappa opioid receptor 1 100.00 antagonist 3 95.80 Morphine 4 93.08 narcan 3 87.44 agonist 2 81.92 opioid receptor 1 75.00

Disease Link Frequency Relevance Heat Hypothermia 6 99.08 Fever 2 97.72 Body Temperature Changes 1 68.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is suggested that PCP may affect thermoregulation through mu and/or kappa opioid receptor mechanisms.

PCP Spec (may) Regulation (affect) of kappa opioid receptor associated with kappa opioid receptor

1) Confidence 0.41 Published 1986 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3020223 Disease Relevance 0.77 Pain Relevance 0.71

General Comments

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