INT339499

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0

nucleus (Socs1, Eif2ak2) RNA binding (Eif2ak2) intracellular (Eif2ak2) translation (Eif2ak2) kinase activity (Eif2ak2)

Socs1 (Mus musculus) Eif2ak2 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 42 50.00 palliative 1 15.44 Inflammation 8 5.00 cytokine 5 5.00 agonist 3 5.00 Inflammatory mediators 1 5.00 addiction 1 5.00 chemokine 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 3 88.16 Sepsis 10 30.80 INFLAMMATION 9 5.00 Infection 5 5.00 Disease 2 5.00 Bacterial Infection 1 5.00 Necrosis 1 5.00 Attention Deficit Hyperactivity Disorder 1 5.00 Cancer 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The capacity of SOCS-1 to interact physically with and catalyze degradation of PKR in HEK293T cells supports the possibility that SOCS-1 regulates PKR protein levels during the TLR4-mediated response to LPS.

SOCS-1 Regulation (regulates) of Gene_expression (levels) of PKR

1) Confidence 0.05 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.