INT339514

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Socs1, Eif2ak2) RNA binding (Eif2ak2) intracellular (Eif2ak2)
translation (Eif2ak2) kinase activity (Eif2ak2)
Socs1 (Mus musculus)
Eif2ak2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 84 50.00 Quite Low
Inflammation 16 28.80 Quite Low
cytokine 10 28.12 Quite Low
palliative 2 14.24 Low Low
agonist 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 86.96 High High
Sepsis 20 29.60 Quite Low
INFLAMMATION 18 28.80 Quite Low
Infection 10 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Bacterial Infection 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the effects of SOCS-1 on PKR protein levels may be the result of regulation of an intermediate element, we evaluated the potential for SOCS-1 and PKR to interact physically in our overexpression system.
SOCS-1 Regulation (effects) of PKR
1) Confidence 0.07 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0
The capacity of SOCS-1 to interact physically with and catalyze degradation of PKR in HEK293T cells supports the possibility that SOCS-1 regulates PKR protein levels during the TLR4-mediated response to LPS.
SOCS-1 Regulation (regulates) of PKR
2) Confidence 0.03 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.09 Pain Relevance 0

General Comments

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